Figure 3.
Figure 3. (A) Structural alignment of PurS (blue) with the
N-terminal domain of lgPurL (gray) from S. typhimurium C[ ]atoms
from the dimer of TM1244 were used for the alignment with
lgPurL. The largest structural difference corresponds to strand
3
of chain A, which is replaced by a long loop (see arrow) that
acts as a linker between the adjacent PurS-like domains in
lgPurL. (B) Stereo ribbon diagram of a superposition of lgPurL
from S. typhimurium (FGAR-AT; gray) with PurS (TM1244; blue) and
smPurL (TM1246; orange). Ligands of lgPurL are shown as CPK
(Corey, Pauling, and Kultun) color scheme. The arrow indicates
the expected location of the PurQ protein (TM1245) in FGAR-AT
from T. maritima.
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2006,
65,
249-254)
copyright 2006.
]atoms
from the dimer of TM1244 were used for the alignment with
lgPurL. The largest structural difference corresponds to strand
3
of chain A, which is replaced by a long loop (see arrow) that
acts as a linker between the adjacent PurS-like domains in
lgPurL. (B) Stereo ribbon diagram of a superposition of lgPurL
from S. typhimurium (FGAR-AT; gray) with PurS (TM1244; blue) and
smPurL (TM1246; orange). Ligands of lgPurL are shown as CPK
(Corey, Pauling, and Kultun) color scheme. The arrow indicates
the expected location of the PurQ protein (TM1245) in FGAR-AT
from T. maritima.