|
Figure 4.
Figure 4. The N517Q mutation in the G design induces a
backbone shift in the DNase. Overlay of the design model (teal
and yellow side-chains) with the experimentally determined
structure (magenta and orange side-chains). The Q517 side-chain
in the G design crystal structure does not displace a tightly
bound water molecule (magenta, W12) resulting in a backbone
shift to accommodate a different Q side-chain rotamer. The
immunity protein backbones are colored in gray.
|
