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Figure 3.
Figure 3. Ligand-Receptor Contacts between Artemin and
GFRa3
(A) Molecular surfaces highlight the knob-in-hole
complementarity between the protruding ARTN finger region (cyan)
and the recessed center of a triangular spiral of a helices in
GFRa3 D2 (deep salmon) formed by helices a1, a2, and a5.
(B) Interatomic contacts between ARTN and GFRa3, with the
hydrophobic core of ARTN surrounded by a halo of polar
interactions.
(C) Electrostatic footprints and
complementarity of buried residues of ARTN on top of the GFRa3
surface.
(D) Electrostatic footprints and complementarity
of buried residues of GFRa3 on top of the ARTN surface.
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