Figure 3.
Figure 3: Crystal structure of the designed enzyme–DNA
complex. Left, F[o]–F[c] electron-density map of the
redesigned region calculated from a refinement model lacking the
redesigned side chains and bases (cyan). The computational
design model (grey) fits well into the unassigned density (blue
mesh, +2.2 ).
Right, superposition of the design model (salmon) and the
refined crystal structure (cyan) confirms the accuracy of the
design. A new coordinated water molecule (red sphere) is also
apparent.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2006,
441,
656-659)
copyright 2006.
).
Right, superposition of the design model (salmon) and the
refined crystal structure (cyan) confirms the accuracy of the
design. A new coordinated water molecule (red sphere) is also
apparent.