Figure 3.
Figure 3 Surface representation of the 20
Å deep funnel leading to the catalytic site. Blue,
side-chain nitrogens of Arg and Lys residues; red, side-chain
oxygens of Asp and Glu; green, side-chain carbons of Tyr and Phe
residues. Yellow, Zn^2+ ions; inhibitors shown as stick models.
(A) Complex with GPI-18431; (B) complex with phosphate. Note the
difference in the shape of the pocket because of withdrawal of
the 'glutarate sensor' (Y700) in the phosphate complex.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2006,
25,
1375-1384)
copyright 2006.
20
Å deep funnel leading to the catalytic site. Blue,
side-chain nitrogens of Arg and Lys residues; red, side-chain
oxygens of Asp and Glu; green, side-chain carbons of Tyr and Phe
residues. Yellow, Zn^2+ ions; inhibitors shown as stick models.
(A) Complex with GPI-18431; (B) complex with phosphate. Note the
difference in the shape of the pocket because of withdrawal of
the 'glutarate sensor' (Y700) in the phosphate complex.