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Figure 3.
Fig. 3. The suPAR-ATF binding surface. The carbon atoms of the
D1 domain of uPAR are shown in orange, the D2 in magenta, and
the D3 in orange. The ATF is shown in a ribbon diagram in cyan.
(A) Molecular surface representation of the overall suPAR-ATF
binding. The three uPAR domains form a conical cavity with a
wide opening (25 Å) and large depth (14 Å) that are
involved in the ATF binding. (B) Surface representation of the
uPAR-ATF binding. The circled areas are regions 1 and 2 (from
left to right) of uPAR-ATF interface. Oxygen atoms are shown in
red, nitrogen atoms in blue, and sulfur in yellow. Waters
involved in uPAR-ATF binding are shown as red spheres. Hydrogen
bonds are shown as dashed lines (light blue). (C) Detailed
interaction of suPAR (ribbon representation) and the ATF in
stereoview. Thr8, Arg53, Glu68, Thr127, and His166 of suPAR form
hydrogen bonds with Ser21, Lys23, Tyr24, Ser26, and Gln40 of
ATF.
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