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Figure 3.
Fig. 3. Modeled trimer and coreceptor schematic. (A) V3 in the
context of a trimer at the target cell surface. The structure of
the CD4-triggered gp120 with V3 was superimposed onto the
structure of four-domain CD4 (39) and the trimer model obtained
by quantification of surface parameters (32). In this
orientation, the target cell membrane and coreceptor are
expected to be positioned toward the bottom of the page. (B)
Schematic of coreceptor interaction. CCR5 (green) is shown with
its tyrosine-sulfated N terminus (at residues 3, 10, 14, and 15)
and three extracellular loops (ECLs). V3 (red) is shown with its
conserved base interacting with the sulfated CCR5 N terminus and
its flexible legs allowing its conserved V3 tip to reach the
second ECL of CCR5.
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