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Figure 3.
Fig. 3. Stereoview of the active center of hTK1. Water
molecules are red balls, hydrogen bonds are dashed lines. (A)
Bound feedback inhibitor dTTP with hydrogen bonding network. The
conformation of dTTP in its two binding modes was derived from
the F[o]–F[c] omit electron density map here contoured at 3σ
(green). The 40% binding mode is shown in a semi transparent
mode. (B) The nucleotide is bound by the tight interactions with
protein residues. Hydrogen bonds to main chain atoms and
stacking of the pyrimidine ring between Phe101, Phe133 and
Tyr181 are responsible for the high substrate specificity.
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