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Figure 3.
FIG. 3. Ligand interactions with the hinge region:
comparison with PKA. Structures of Pim-1 and PKA bound to
staurosporine and adenosine were aligned to optimize the
superposition of residues adjacent to the hinge regions. The
Pim-1 structure is colored by atom type and labeled in black,
and PKA is drawn and labeled in pink. Hydrogen bonds are
depicted as green dotted lines. The view is rotated  90°
from Fig. 2. In this orientation, the glycine-rich loop lies
above and in the plane of the page. A, the structures of the
PKA·staurosporine (Protein Data Bank code 1STC [PDB]
) and Pim-1·staurosporine complexes. B,
Pim-1·adenosine and PKA complexes (Protein Data Bank code
1FMO [PDB]
). C, sequence alignments of hinge regions. Residues that accept
and donate hydrogen bonds to the adenine ring of ATP are
highlighted in red and blue, respectively.
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