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Figure 3.
Figure 3. The antithrombin reactive center loop conformation and
contacts with thrombin. (a) Stereo view of the antithrombin
RCL from P7 to P6' (ball and stick) interacting with the surface
of thrombin portrayed using GRASP. The residues P7 to P6' are
Ala-Val-Val-Ile-Ala-Gly-Arg-Ser-Leu-Asn-Pro-Asn (the scissile
P1-P1' residues are underlined). (b) Stereo view of contacts
between the antithrombin RCL from P7 to P6' (cyan) and residues
in and around the thrombin active site (green), using a
transparent view of the thrombin surface (gray). The orientation
is the same in both views.
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