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Figure 3.
Fig. 3. The conformational changes that occur in the two switch
regions and the neck-linker region during ATP hydrolysis. (A to
D) AMP-PCP (A), AMP-PNP (B), ADP-AlFx (C), and ADP-Vi (D) forms
are shown in light brown, red, blue, and green, respectively.
These panels are seen from the upper right in Fig. 2A (indicated
by the black arrow). Nucleotides and the coordinating residues
around them are shown as ball-and-stick models. Missing
C-terminal residues and loops are shown by dashed lines. The
structural details around the nucleotide-binding pocket are also
shown in figs. S2 to S4 (46). (E and F) The conserved salt
bridge between Glu170 and Arg316 (enclosed by a red circle),
shown in ball-and-stick models in the AMP-PNP (E) and ADP-Vi (F)
forms. Loop L8 and the switch II cluster are shown in dark blue
and dark red, respectively. Nucleotides are shown as
space-filling models.
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