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Figure 3.
Figure 3. Interactions of HDAC8 with Inhibitors and
Substrate(A) Stereo figure showing key residues in the HDAC8
active site, two TSA molecules (blue and pink), the zinc
(orange), and the sodium (purple). Potential hydrogen bonds are
depicted as dashed lines.(B) F[o] - F[c] simulated annealing
omit maps showing the electron density for the two molecules of
TSA. The maps were contoured at 2.5s and are shown within 1.8 Å
of the TSA molecules.(C) Schematic diagram showing the binding
of the hydroxamate inhibitors to HDAC8.(D) Schematic diagram
showing the proposed model of how the acetylated lysine would
interact with the HDAC catalytic machinery.
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