Figure 3.
Fig. 3. Comparison of human NEIL1 with other Fpg/Nei DNA
glycosylases. (A) Superposition of human NEIL1 (blue) with
EcoNei (pink; PDB ID code 1K3W [PDB]
) (20) and TthFpg (green; PDB ID code 1EE8 [PDB]
) (21). The region encompassing the zinc-finger motif is boxed.
An arrow points to the location of the F- 10 loop in Fpg. (B)
Close-up of the zinc-finger motif. Shown are residues 230-262
for EcoNei, 231-266 for TthFpg, and 263-290 for human NEIL1. The
asterisks indicate the position of the C of the conserved
arginine.
F- 
10 loop in Fpg. (B)
Close-up of the zinc-finger motif. Shown are residues 230-262
for EcoNei, 231-266 for TthFpg, and 263-290 for human NEIL1. The
asterisks indicate the position of the C