Figure 3 - full size

 

Figure 3.
Fig. 3. Tube representation of the tertiary structures of M3 (blue) and streptavidin (magenta) complexes with BNA (shown in black). The L3,4 loop in both molecules is shown in gold. In streptavidin, the loop is in the closed conformation, thus burying the BNA ligand almost completely. In M3, where the loop has three more residues, L3,4 adopts an open conformation. Note the flipping of the amide bond of the ligand and the altered conformation of the p-nitroanilide group.