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Figure 3.
Figure 3: Structure of inactive human vinculin. a, Cartoon
representation of the closed conformation of vinculin (Vh,
residues 1 -258, pink; Vt, 879 -1066, light blue). b, c,
Electrostatic surface potential (red, negative; blue, positive)
of the Vh -Vt complex. b, Head-on view of each interface (left,
Vh; right, Vt) when Vh and Vt are taken apart (that is, Vh is
rotated 90° to the left and Vt is rotated 90° to the right with
respect to the orientation shown in a). Residues involved in
interdomain contacts are labelled. c, Same orientation as in a,
revealing the acidic pocket created when Vh binds to Vt. Acidic
residues lining the pocket are indicated in yellow.
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