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Figure 3.
Figure 3. Stereoscopic diagram of the PGHS monomer. The
structural domains are colored as follows: the EGF-like domain,
green; the membrane-binding domain, yellow; and the catalytic
domain, blue. The cyclooxygenase inhibitor
a-methyl-4-biphenylacetic acid is depicted as an orange
space-filling model, and glycerol molecules are depicted as pink
space-filling models. PGHS features three sites of
glycosylation, Asn68, Asn144, and Asn410. The carbohydrate
molecules are shown in yellow ball-and-stick representations.
Several molecules of the non-ionic detergent b-OG (black and red
ball-and-stick) used in the crystallization of PGHS are bound
near the membrane-binding domain. This Figure was prepared using
MOLSCRIPT.[85.]
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