Figure 3 - full size

 

Figure 3.
Figure 3. Kabiramide C binding to the actin filament may result in steric clashes with the neighboring actin subunit. Kabiramide C in G-actin-bound conformation (red) is superimposed onto the model for F-actin31, 33. For clarity, four actin subunits are depicted where the filament axis is vertical with the barbed end at the bottom. The two in the front, shown in blue and green, reveal the location of kabiramide between longitudinally contacting actin monomers.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Biol (2003, 10, 1058-1063) copyright 2003.