Figure 3.
FIG. 3. Close up view of the DesIV active site. A close up
view of the active site, within 3.2 Å of the NAD^+
and dTDP ligands, is shown in a. For the sake of clarity, Ser87
and His88 were omitted from the figure. The side chain hydroxyl
group of Ser87 interacts with a phosphoryl oxygen of the NAD^+
while N 2 of His88 forms a
hydrogen bond with a phosphoryl oxygen of the dTDP. A schematic
of the hydrogen-bonding pattern around dTDP is displayed in b.
Possible hydrogen-bonding interactions within 3.2
Å are indicated by dashed lines.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
2211-2220)
copyright 2004.
3.2 Å of the NAD^+
and dTDP ligands, is shown in a. For the sake of clarity, Ser87
and His88 were omitted from the figure. The side chain hydroxyl
group of Ser87 interacts with a phosphoryl oxygen of the NAD^+
while N 
2 of His88 forms a
hydrogen bond with a phosphoryl oxygen of the dTDP. A schematic
of the hydrogen-bonding pattern around dTDP is displayed in b.
Possible hydrogen-bonding interactions within