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Figure 5.
Figure 5. A Model of the Interaction between the EAA Loops
of MalF and MalG Transmembrane Proteins and the Q Loop of
MalK(A) Model of the docking of the L loop of BtuC to the Q loop
of MalK. To obtain this model, the NBD of MalK from the
ATP-bound structure was aligned with the NBD of BtuCD. Color
codes: cyan, the BtuC L loop; blue, the Q loop of MalK; red and
purple, the Walker A motif of one subunit and the LSGGQ motif of
the other subunit, respectively. ATP is shown in
ball-and-stick.(B) Predicted helix-loop-helix motif of the EAA
loops of MalF and MalG. The L loop in the crystal structure of
BtuCD, which displays a helix-loop-helix configuration (Locher
et al., 2002), is the equivalent of the EAA loops.
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