|
Figure 3.
Figure 3. Schematics of PDZ Interactions(A) Canonical PDZ
binding of C-terminal sequence depends on the residues P[0] and
P[ -2] binding pockets S[0] and S[ -2].(B) All three C-terminal
residues are involved in the interaction to PDZ binding
groove.(C) The C-terminal binding depends on the binding at S[
-1] and S[ -2] of PDZ as seen in PDZ2-syndecan-4 peptide
complex.(D) The C-terminal binding depends on the binding at
S[0] and S[ -1] as seen in syntenin PDZ2-interleukin 5 receptor
a subunit peptide complex.(E) Syntrophin PDZ interaction by the
residues from b-finger conformation of nNOS.(F) Interaction of
internal residue at pocket S[ -2] while C-terminal residues
binds at S[0] as seen in syntenin PDZ2-PDZ2 interaction.
|
