Figure 3.
Figure 3. Docking and superposition of the native (green) and
ATP-bound (red) N-domain of NaK 1,
the E2(TG) form of Ca-ATPase (violet) and E1 form of H-ATPase
(blue). (a) Solution structure of the ATP-bound N-domain of
NaK 1
and the crystal structure of the E2(TG) form of SERCA1a docked
in the 11-Å Cryo-EM structure of Na,K-ATPase illustrating the
relative positions of the three cytosolic domains, the TM-domain
and the subunit,
as well as the difference in positions of the N-domains. The
surface corresponds to 75%
of the expected molecular volume. (b) Enlarged view of the
native and ATP-bound N-domains of NaK 1.
(c) Superposition of native and ATP-bound N-domain with the
E2(TG) form of Ca-ATPase. (d) Superposition of native and
ATP-bound N-domain with the model for the E1 form of H-ATPase.
Panels c and d focus on residues in the hinge region between the
N- and P-domains.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2003,
10,
468-474)
copyright 2003.
1,
the E2(TG) form of Ca-ATPase (violet) and E1 form of H-ATPase
(blue). (a) Solution structure of the ATP-bound N-domain of
NaK 
1
and the crystal structure of the E2(TG) form of SERCA1a docked
in the 11-Å Cryo-EM structure of Na,K-ATPase illustrating the
relative positions of the three cytosolic domains, the TM-domain
and the 
subunit,
as well as the difference in positions of the N-domains. The
surface corresponds to 
75%
of the expected molecular volume. (b) Enlarged view of the
native and ATP-bound N-domains of NaK