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Figure 3.
Figure 3. The Model of the BMP7/ActRII/BMPRIa Six-Chain
Signaling ComplexBMPRIa (purple) was placed in the complex by
aligning the BMP2/BMPRIa structure (Kirsch et al., 2000a) with
BMP7.(A) Side view as in Figure 1A is shown as a solvent
accessible surface. The horizontal line represents the plane of
the membrane.(B) Bottom view (opposite from Figure 1B). Sugars
are in black. The C termini are marked with yellow dots and the
horizontal distances between them as projected onto the plane of
the membrane are 83 Å for type II-type II, 66 Å for
type I-type I, and 27 Å and 68 Å for type I-type II.
(A) and (B) were prepared with DINO (Philippsen, 2001).(C)
Stereo view of ActRII and TGF-βRII bound to their respective
ligands overlaid with the BMP2/BMPRIa structure. The BMP7/ActRII
complex was aligned as in (A) using the entire ligand. In order
to overlay the TGF-βRII binding site (tip of finger 2 on
TGF-β3) with BMP2, only 14 residues (86–92 and 98–104 of
BMP2) were used for the alignment (Hart et al., 2002). The color
scheme is BMP2, white; BMP7, gold; ActRII, green; TGF-β3, blue;
TGF-βRII, red; BMPRIa, purple. The receptors and their C
termini are labeled.
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