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Figure 3.
Fig 3. FIH-1 structure contains a  -jellyroll core marked
by an extension of one of the -sheets away from the
core and helices dotting the periphery. (A) A ribbon model of
the FIH-1 monomer is positioned looking between the -sheets
comprising the jellyroll and into the active site cavity. The
active site metal is shown as a red sphere. Structural elements
are colored as in Fig. 2. (B) A secondary structure topology
diagram shows the arrangement of the 14 -strands (triangles) and
8 helices (circles) in FIH-1. The core jellyroll motif,
structurally homologous to the cupin protein family, is colored
in red. (C) FIH-1 exists as a functionally relevant dimer in the
crystal. The first monomer of the dimer is colored as in A,
whereas the second monomer is blue. N and C termini are marked
as black circles. The figure was generated by using RIBBONS (41).
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