Figure 3 - full size

 

Figure 3.
Figure 3 Model of the tertiary structure of the pcDHFR-NADP+-(2) ternary complex. Helices are in yellow, sheets are in red and loops are in green. Active-site hydrophobic residues Leu25, Ile33, Pro66, Phe69 and Ile72 are shown. Models were produced with SETOR (Evans, 1993[Evans, S. V. (1993). J. Mol. Graph. 11, 134-138.]).

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (2002, 58, 1393-1399) copyright 2002.