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Figure 3.
Figure 3. Comparison of bound aminoglycosides and the chemical
mechanism of acyltransfer by AAC(2')-Ic. a, Stereo view of
the superposition of tobramycin (blue), kanamycin A (green), and
ribostamycin (red) in the aminoglycoside -AAC(2')-Ic complexes.
The five water molecules that are conserved in all three ternary
complexes are shown as red spheres. Protein coordinates are from
AAC(2')-Ic in complex with ribostamycin and CoA. b, Chemical
reaction mechanism of AAC(2')-Ic based on the AAC(2')-Ic ternary
complexes.
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