|
Figure 3.
Figure 3. Solution Structure of CH1[1](A) Stereoviews of
the best 20 structures. Structures are superimposed for best fit
over backbone atoms of residues 1-23 (note that residues 25-27
are not displayed, for clarity). Zinc-ligating side chains, red;
zinc atom, gray; side chains of well-defined residues (2, 4, 7,
9, 12, 16, 21, and 22), green.(B) Ribbon diagram of the lowest
energy structure of CH1[1]. The secondary structural elements
recognized by the program MOLMOL [33] are shown.(C) Schematic
zinc binding domain. Zinc binding domains can generally be
thought of as two bidentate zinc-ligating motifs separated by an
intervening sequence of highly variable length.(D) Overlay of
the C-X[4]-C motifs in CH1[1] and TAZ2. Residues 5-10 of CH1[1]
have been overlayed with residues 28-33 of TAZ2 (yellow) using
the backbone atoms only. The rmsd is 0.42 Å.(E) Overlay of the
H-X[3]-C motifs in CH1[1] and TAZ2. Residues 16-23 of CH1[1]
have been overlayed with residues 39-46 of TAZ2 (yellow) using
the backbone atoms only. The rmsd is 0.43 Å.
|
