Figure 3 - full size

 

Figure 3.
Fig. 3. US2 binds remotely from peptide-loading proteins. The positions of mutations (blue) that alter interactions between class I molecules and the peptide-loading machinery are shown relative to the US2 binding site on HLA-A2 (magenta). The HLA-A2 N-linked glycan attachment site, asparagine 86, is also shown in blue. US2 residues that contact HLA-A2 are yellow.