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Figure 3.
Fig. 3. Stereo views showing interactions of the ribosome with
the codon-anticodon base pairs. The tightness of the
interactions is shown by the semitransparent van der Waals
surface. (A) In the first position, A1493 binds in the minor
groove of the A36-U1 base pair. (B) In the second position, G530
and A1492 (both brown) act in concert to monitor the A35-U2 base
pair. (C) The third (wobble) position, showing the G34-U3 base
pair. C1054 stacks against G36 of the ASL. U3 interacts with
G530, and indirectly through a Mg2+ ion (magenta) with C518 and
residue Pro48 (E. coli Pro44) from protein S12 (gray). The base
pair seems closer to Watson-Crick geometry. (D) The third
position in the presence of paromomycin, with the expected GU
wobble pair. The interactions with the ribosome are similar to
those in (C).
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