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Figure 3.
Figure 3. A Comparison of the Rop and Ala[2]Ile[2]-6
StructuresRop is shown in blue and Ala[2]Ile[2]-6 is shown in
yellow. The labels for the polypeptide termini use a subscript
to denote either protomer A or B. The key phenylalanine at
position 14, at the center of the RNA binding interface, is
shown in ball-and-sticks on each protomer to aid viewer
orientation.(a) Side-by-side view showing the loops of
Ala[2]Ile[2]-6 at the same end of the four-helix bundle and the
splitting of the Helix1-Helix1' binding face (pointing out of
the page) of wild-type Rop.(b) Overlay view with protomer A (in
the back) of Ala[2]Ile[2]-6 best fit to the backbone of protomer
A of Rop. Helix 2 of the Ala[2]Ile[2]-6 protomers are shifted by
approximately half a turn toward the C terminus with respect to
Rop
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