Figure 3.
Figure 3. The active site. a, The inhibitor Neu5Ac2en bound
in the active site of the hexagonal crystal form. b, The same
active site as observed in the ligand-free pH 4.6 orthorhombic
crystal structure. c, The -anomer
of sialic acid bound in the active site of the pH 4.6
orthorhombic crystal form, showing hydrogen bonding interactions
(dotted lines). Water molecules are labeled W.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2000,
7,
1068-1074)
copyright 2000.
-anomer
of sialic acid bound in the active site of the pH 4.6
orthorhombic crystal form, showing hydrogen bonding interactions
(dotted lines). Water molecules are labeled W.