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Figure 3.
Figure 3. Stereo diagrams of the active site of mouse ADH2
complexed with NADH and N-cyclohexylformamide (CXF). (a), The
alternative proton relay via Thr48 and Asn51 is indicated with
broken lines and distances are given in Å (red). The 2F[o]
-F[c] electron density map (blue) is contoured at 1s and the
annealed omit F[o] -F[c] electron density map for CXF is
contoured at 2.5s (red). Two of the four zinc ligands are
depicted with the coordination to the zinc indicated with dashed
lines. (b) Stereo diagram showing all residues lining the
substrate pocket.
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