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Figure 3.
Fig. 3. The dimer of the TrxR-Trx complex with TrxR in the FR
conformation, viewed down the molecular dyad. Blue and cyan
denote one monomer of the TrxR dimer; gold and yellow denote the
second monomer. The TrxR-Trx protomer on the right is designated
A; the protomer on the left is B. These are related to protomers
C and D, respectively, by NCS. Each NADPH domain contacts both
of the FAD domains of the dimer. The thioredoxin substrates
(gray), which bind and react at opposite ends of the TrxR dimer,
are accommodated by the FR conformation. FAD, AADP+, and the
TrxR-thioredoxin cross-link (sulfurs in green) are drawn in
ball-and-stick mode.
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