Figure 3 - full size

 

Figure 3.
Figure 3: GRASP11 surface representation of the dimeric intimin-Tir IBD complex. The viewing direction is approximately parallel to the dimerization dyad. Accessible surfaces colour-coded with electrostatic potential (-15 for red, +10 for blue) are shown for one intimin (on the left) and one Tir IBD (in the centre). The other intimin (in blue) and Tir IBD (in pink) are shown as worm models. Although Tir IBD has an overall net negative charge (seven net negative charges) the dimerization interface between the two Tir molecules is minimally charged. Intimin has a complementary overall positive charge (six net positive charges) with a positively charged tip close to the -helices of the Tir IBD dimer.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nature (2000, 405, 1073-1077) copyright 2000.