|
Figure 3.
Figure 3. Interactions of the Lac repressor with operator and
ONPF. a, Stereo view of the ONPF binding pocket. The
anti-inducer ONPF, and the side chains of residues of the
repressor that make contacts to ONPF, are shown in
ball-and-stick representation. Hydrogen bonding interactions are
shown as dotted lines. For clarity, several hydrophobic residues
that line the binding pocket are not shown. b, Stereo view of
the interactions between the hinge helices of the repressor and
the minor groove of the operator. The two DNA strands are shown
in green and yellow, while the two subunits of the repressor are
shown in blue and brown. Side chains of the repressor that
contact the operator directly are highlighted in ball-and-stick
representation. Notice that the two Leu 56 side chains of the
repressor wedge into the minor groove, at the center of the
operator.
|
