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Figure 3.
Fig. 3. Molecular surface representation of the consensus
binding site on IgG-Fc [coordinates from Deisenhofer (3)]. (A)
Fc with superimposed binding interfaces of Protein A, Protein G,
and rheumatoid factor. (The 4.5 Å crystal structure of the
Fc-receptor/Fc complex was excluded because of its low
resolution.) Atoms are colored blue, yellow, or red depending on
whether they are involved in one, two, or three of the
interfaces, respectively (17). (B) As in (A) with the interface
of the Fc binding peptide (Fc-III) superimposed in green. Fc-III
interacts with many of the atoms that are found in the
interfaces of the other three Fc binding proteins.
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