|
Figure 5.
Figure 5. 5′-Ura-Cyt-Ade-Cyt-3′ Binding by Nova-2
KH3RIBBONS drawings showing the RNA-binding surface sandwiched
between the invariant Gly-X-X-Gly motif (yellow) and the
variable loop (red). The portion of the stem loop
crystallization RNA making extensive protein contacts has been
included as a color-coded stick figure (Figure 2) with the
aliphatic residues (gray) comprising the hydrophobic α/β RNA
binding platform. (A) shows the entire complex. (B), (C), and
(D) show the environments of Ade-11 Ura-12, and Cyt-13,
respectively. (E) shows the environments of Ade-14 and Cyt-15.
The side chain of Leu-28 is denoted with *. (F) corresponds to
the views used in (D) and (E), with the overlying RNA removed,
and shows the aliphatic platform with the jaws of the molecular
vise.
|
