|
Figure 3.
Figure 3. Structure comparison of HCV RdRp with poliovirus
RdRp and HIV RT and with the Mrf-2 DNA-binding domain. (a)
Stereoview of superimposed wire models of the a- and b-fingers
subdomains and palm domain of HCV RdRp and the corresponding
portions of poliovirus RdRp [13] and the ternary complex of HIV
RT [24]. The a fingers, b fingers, and palm of HCV RdRp are
shown in green, cyan, and pink, respectively. Poliovirus RdRp is
shown in silver and HIV RT is shown in gold. The positively
charged residues mentioned in the text are represented by blue
balls and sticks. In the b-fingers subdomain, the basic residues
are Lys51, Arg48, Arg158, Lys155 and Lys141 from the outside. In
the a fingers, the residues are Lys98, Arg168, Lys172, Lys90,
Arg109 and Lys106 from the top right in a clockwise direction.
(b) Stereoview of superimposed wire models of the thumb domains
of HCV RdRp (violet), poliovirus RdRp (silver) [13] and HIV RT
(gold) [24]. (c) Stereoview of superimposed wire models of the
a-fingers region, including its connecting b1-b2 loop in the
b-fingers subdomain (residues 74-189), of HCV RdRp (blue) and
the Mrf-2 DNA-binding domain (red) [25].
|
