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Figure 3.
Figure 3. Detailed Interactions for the Major Consensus
Motif (P/S/A/T)x(Q/E)EShown is the stereo diagram of the
interaction between the TRAF domain and the CD40 peptide, with
the molecular 3-fold axis vertical. The TRAF domain is
represented by purple worm-and-stick models, with carbon atoms
in gray. The peptide is shown as a stick model, with carbon
atoms in yellow. The side chain at the P[−1] position and the
entire chain after the amide of the P[2] position are omitted
for clarity. The conformations of the two CD40 peptides with
different lengths (Table 1) are essentially identical. Atoms
within hydrogen-bonding distances are connected with black
dotted lines. The β strands in the path of the peptide and
selected residues in the TRAF domain are labeled. Note the
interactions at the P[−2], P[0], and P[1] positions of the
peptide.
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