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Figure 3.
Figure 3. Structures of Two Murine eIF4E/7-methyl-GDP/Peptide
Ternary ComplexesRibbon diagrams of the eIF4E
(blue)/7-methyl-GDP (ball-and-stick representation)/peptide
ternary complex structures viewed perpendicular to the eIF4E’s
β sheet (A and C) and in profile, rotated 90° about the
vertical from the previous view (B and D). 7-methyl-GDP is
located in the cap-binding slot on the convex face of eIF4E, 35
Å from peptide binding site.Upper: The eIF4GII peptide
(orange) forms an L-shaped structure that interacts with the N
terminus of eIF4E and two of three long α helices (H1 and H2)
on its convex dorsal surface.Lower: The 4E-BP1 peptide (yellow)
adopts a very similar conformation on binding to eIF4E.
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