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Figure 3.
Fig. 3. ElonginC binds VHL and ElonginB across two separate
interfaces. (A) The VHL-ElonginC interface consists of an
intermolecular hydrophobic four-helix cluster augmented by
additional contacts. VHL and ElonginC secondary structural
elements are shown in red and blue, respectively. VHL amino
acids are in yellow and those of ElonginC are in cyan. Hydrogen
bonds are indicated by white dashed lines. Red atoms indicate
oxygen and blue, nitrogen. A red circle with the letter "M"
indicates a residue that is one of the six most frequently
mutated in cancer. The ElonginC pocket where the VHL Leu^158
binds is made up of Tyr^76, Phe^93, Leu^103, and Ala^107, and
Cys^112 (40). (B) The parallel  strand-
strand
interaction around which the ElonginC-ElonginB interface centers
is indicated by a two-headed arrow (four hydrogen bonds).
ElonginB and ElonginC secondary structural elements are shown in
green and blue, respectively. ElonginB amino acids are in
magenta and those of ElonginC are in cyan.
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