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Figure 2.
Figure 2 The complex of human H-Ras with the exchange-factor
region of human Sos1. a, The N-domain of Sos (residues 568-741)
is shown blue; the catalytic domain (residues 752-1044) is
green; the Switch 1 and Switch 2 segments and the P-loop region
of Ras (as defined here) are orange and red, respectively;
conserved regions (SCRs) among Ras-family exchange factors are
cyan2,17. Disordered residues of Sos are shown as dotted lines.
This and all other ribbon diagrams were generated using
RIBBONS44. b, The Ras-Sos complex is shown with the catalytic
domain of Sos depicted as a molecular surface. Conserved
residues Ile 956 and Phe 958 in the catalytic domain that form a
hydrophobic interface with the N-domain are labelled. This and
all other figures with molecular surfaces were generated using
GRASP45.
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