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Figure 2.
Figure 2. mRNA–VP39 Complex(A) Stick model showing RNA
bound to the active site cleft of VP39. The protein is rendered
as a solvent-accessible surface. The sulfur atom of AdoHcy
(colored green and labeled with an arrow) defines the
methyltransferase active site.(B) The two RNA contacts mapped on
a single VP39 molecule resulting from the interaction of the RNA
with two symmetry-related protein molecules. The protein is
rendered as a transparent solvent-accessible surface. Shown in
front of the protein is the second trimer (A4-A5-A6) binding
site based on the interactions with a symmetry-related molecule.
Behind the protein are the 5′ cap and the first trimer
(G1-A2-A3) of the transcript bound in the methyltransferase
active site.(C) The proximity of the second RNA contact site to
the VP55 dimerization interface. The major red patch denotes
surface residues defined in [20] as the VP55 dimerization 'hot
spot.' The smaller red patch (R107 to the right) is another part
of the dimerization interface (see [20]). This figure was
produced using GRASP ( [17]).
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