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Figure 2.
Figure 2. Structure of the STAT-1 DNA Complex(A) Ribbon
diagram of the STAT-1 core dimer on DNA. The component domains
are colored green (coiled-coil domain), red (DNA-binding
domain), orange (linker domain), cyan (SH2 domain). The tail
segments are shown in magenta and yellow. Disordered loops (one
in the coiled-coil domain and one connecting the SH2 domain to
the tail segment) are shown as dotted lines. The phosphotyrosine
residue is shown in a stick representation. The N and C termini
of STAT-1 core are indicated by “N” and “C”. The DNA
backbone is shown in gray. This and other ribbon diagrams were
rendered using RIBBONS ([6]).(B) Molecular surface of the STAT-1
dimer in the same orientation as (A). The surface was calculated
using GRASP ([31]) and rendered using RASTER3D ( [28]). The tail
segments, shown in green and magenta, were not included in the
surface generation. The surface is colored according to the
local electrostatic potential, with blue and red representing
positive and negative potential, respectively.
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