Figure 2.
Fig. 2. Stereo views of PKCI in (A) apo, (B) AMP-CP substrate
analog, (C) adenosine-tungstate transition-state^ analog, and
(D) AMP product-bound forms. The region shown was selected to
highlight interactions between the ligand and^ protein residues
surrounding one of the two equivalent ligand-binding sites in
the HIT homodimer. A subset of residues is shown superimposed^
on the C backbone
cardinal spline of each respective structure. Hydrogen bonds are
denoted by dotted lines. The tryptophan shown is in the
COOH-terminal tail of the other protomer. Figure generated^ with
Setor (15).
The above figure is reprinted
by permission from the AAAs:
Science
(1997,
278,
286-290)
copyright 1997.
backbone
cardinal spline of each respective structure. Hydrogen bonds are
denoted by dotted lines. The tryptophan shown is in the
COOH-terminal tail of the other protomer. Figure generated^ with
Setor (15).