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Figure 5.
Fig. 5. Stereo diagram showing the location f
thehydrophobicinternal cavity (dot surface)
found in wild-type iso-1 cytochrome c. he
heme group and nearby side chains that define
the outer limits of this cavityin the L85F (thick
lines) nd L94S (thin lines) mutant proteins
havebeen superimposed onthe structure of te
wild-type protein (medium lines). The differ-
ent conformations observed for he Leu98 side
chain are largely responsible for determining
the size ofthis internal cavity. In the L85F mu-
tant protein,the Leu 98 side chain moves into
theinternal cavity, effectively eliminating this
feature. In the L94S mutant protein, the Leu98
side chain moves toward the side chain of Ser 94,
causing n increase in cavity size. The volume
and surface area of this in a wide range
of mutantprotins is tabulated in Table 5.
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