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Figure 3.
Putative interaction modes of morphine-based high-affinity
[kgr]-OR-selective antagonists nor-BNI and GNTI.
a, b,
Interaction modes of nor-BNI (a) and GNTI (b). Ligands are
depicted as capped sticks with green carbons, and contact side
chains of the receptor within 4 Å from the ligand are
shown with grey carbons. Key hydrogen bonds and salt bridges are
indicated with small cyan spheres and residues unique to the
κ-OR are labelled in blue. Residue Asp 138^3.32, which also
shows critical impact on GNTI and nor-BNI binding in mutagenesis
studies, is highlighted in red. Ballesteros–Weinstein residue
numbers are shown under the κ-OR residue numbers. The graphics
were prepared using the ICM molecular modelling package (Molsoft
LLC).
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