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Figure 2.
(a) Structure of PAR and fragments; ADPR is the fragment
within the gray area and RFA is that within the blue area (the
darker blue area being common to both). The labels "protein" and
"distal" are purely to indicate chain direction. (b,c)
Structures of RFA bound to APLF F1 (b) and APLF F2 (c). In b,
the RFA molecule is schematically extended to show how PAR may
bind; c shows a close-up of key interactions (including H-bond
adenosyl NH[2]–S426 O, dotted line).
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