|
Figure 2.
Figure 2. Structure of Amino-Terminal and Poly17Q Regions of
Htt17Q-EX1
The structures of the amino-terminal region
(green) and poly17Q region (orange) of Htt17Q-EX1 are shown for
three different molecules with variable lengths of poly17Q α
helix. Also shown are corresponding regions of electron density
maps contoured at 1.0 σ (blue).
(A) The short poly17Q
helix makes a transition to loop at Gln388 (molecule A, crystal
c^95).
(B) The medium poly17Q helix makes a transition to
loop at Gln395 (molecule C, crystal c^90).
(C) The long
poly17Q helix extends for the length of the polyQ region until
Gln402 (molecule C, crystal c[Hg]^99).
|
