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Figure 2.
Co-crystal structure of human RBP4 with A1120. A, overall
view of A1120-bound RBP4 structure. The RBP4 protein is shown in
schematic representation with a spectrum color from blue (N
terminus) to red (C terminus). A1120 is shown in stick
representation with magenta for carbon atoms, red for oxygen
atoms, blue for nitrogen atoms, and pale cyan for fluorine
atoms. The 2f[o] - f[c] electron density map, contoured at 1σ,
for A1120 is shown in gray mesh. B, protein-ligand interactions
for A1120. The protein is shown in both stick (spectrum color)
and molecular surface (wheat color) representations. The
hydrogen bonds between RBP4 and A1120 are shown as black dashed
lines. C, superposition of the A1120-RBP4 co-crystal structure
and retinol-RBP4 co-crystal structure (PDB code: 1RBP). The
carbon atoms are colored in gray for the retinol-bound
structure. D, superposition of the A1120-RBP4 co-crystal
structure on the RBP4·TTR complex structure (PDB code:
1QAB). The TTR tetramer is shown in molecule surface
representation. The RBP4 proteins are shown in schematic
representation with the RBP4 protein shown in gray in the TTR
complex and in spectrum color in the A1120-bound form.
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