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Figure 2.
Cellular activity of indeglitazar and its effect on the
expression of adiponectin and in vivo adiponectin response.
(A–C) Transactivation assay activity of indeglitazar (filled
circles) and reference compound (open circles) in PPARα,
PPARγ, and PPARδ, respectively. Note the partial response of
indeglitazar toward PPARγ. (D) Preadipocyte differentiation
stimulated by rosiglitazone (open circles) and indeglitazar
(filled circles). (E) Taqman analysis of the expression of
adiponectin by mature adipocytes treated by indeglitazar and
rosiglitazone. (F) Effect of indeglitazar and pioglitazone on
adiponectin levels in the ob/ob mice after 14 days of treatment.
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